Table 1.
Classify | Common pairs | Tissue resident | Production of cytokines | |
---|---|---|---|---|
Human | Vδ1 | Vγ2+/3+/4+/5+/8+/9+ | gut, skin, liver PB (peripheral blood) |
IL-10,IL-2,IL-4,IL-17,IFN-γ, TNF-α |
Vδ2 | Vγ9-/9+ | PB, skin | IFN-γ,TNF-α,IL-17,IL-21,IL-24 | |
Vδ3 | Vγ2+/3+/4+ | PB, liver | IL-10,IL-4,IL-17,IFN-γ,TNF-α | |
Murine | Vγ1 | Vγ6.3/6.4 | skin, lung, colon, liver, PB | IL-4,IFN-γ |
Vγ2 | Vδ4 | skin, lung, colon, liver, PB | IL-17 | |
Vγ3 | Vδ1 | skin | ? | |
Vγ4 | Vδ4 | skin, lung, colon, liver, PB, joint |
IL-17,IFN-γ | |
Vγ5 | Vδ1 | skin, liver | IL-17,IFN-γ | |
Vγ6 | Vδ1 | genital tract, togue, lung, colon, skin, adipose tissue |
IL-17,IFN-γ,IL-22 | |
Vγ7 | Vδ4/5/6 | IEL (Intraepithelial lymphocytes) | IFN-γ |
Heilig and Tonegawa nomenclature used for classification.