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. 2021 Feb 25;12:627139. doi: 10.3389/fimmu.2021.627139

Table 1.

Characteristics of human and murine γδT cell subsets.

Classify Common pairs Tissue resident Production of cytokines
Human Vδ1 Vγ2+/3+/4+/5+/8+/9+ gut, skin, liver
PB (peripheral blood)
IL-10,IL-2,IL-4,IL-17,IFN-γ,
TNF-α
Vδ2 Vγ9-/9+ PB, skin IFN-γ,TNF-α,IL-17,IL-21,IL-24
Vδ3 Vγ2+/3+/4+ PB, liver IL-10,IL-4,IL-17,IFN-γ,TNF-α
Murine Vγ1 Vγ6.3/6.4 skin, lung, colon, liver, PB IL-4,IFN-γ
Vγ2 Vδ4 skin, lung, colon, liver, PB IL-17
Vγ3 Vδ1 skin ?
Vγ4 Vδ4 skin, lung, colon, liver,
PB, joint
IL-17,IFN-γ
Vγ5 Vδ1 skin, liver IL-17,IFN-γ
Vγ6 Vδ1 genital tract, togue, lung, colon, skin,
adipose tissue
IL-17,IFN-γ,IL-22
Vγ7 Vδ4/5/6 IEL (Intraepithelial lymphocytes) IFN-γ

Heilig and Tonegawa nomenclature used for classification.