Table 2.
Key DEGs in top 10 BP and top 10 KEGG.
| Category | Gene name | Definition | log2Foldchange | padj |
|---|---|---|---|---|
| Energy substance metabolism | CEL | Bile salt-activated lipase | 4.20 | 7.40E-08 |
| ABCG1 | ATP-binding cassette sub-family G member 1 | 1.63 | 2.35E-04 | |
| ABCG5 | ATP-binding cassette sub-family G member 5 | 1.70 | 2.89E-04 | |
| DGAT1 | Diacylglycerol O-acyltransferase 1 | 2.64 | 4.91E-05 | |
| UGT1A5 | UDP-glucuronosyltransferase 1–5 | 3.46 | 6.59E-05 | |
| UGT2A1 | UDP-glucuronosyltransferase 2A1 | 3.42 | 6.66E-07 | |
| UGT2B31 | UDP-glucuronosyltransferase 2B31 | 2.34 | 3.93E-05 | |
| UGT2C1 | UDP-glucuronosyltransferase 2C1 | 1.96 | 1.30E-04 | |
| COMT | Catechol O-methyltransferase | 2.29 | 8.47E-05 | |
| CYP7A1 | Cholesterol 7-alpha-monooxygenase | 1.87 | 2.54E-04 | |
| EBP | 3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase | 2.00 | 1.46E-04 | |
| DHCR7 | 7-dehydrocholesterol reductase | 2.00 | 1.18E-04 | |
| LSS | Lanosterol synthase | 2.19 | 6.13E-05 | |
| LIPA | Lysosomal acid lipase/cholesteryl ester hydrolase | 1.87 | 1.67E-04 | |
| SQLE | Squalene monooxygenase | 1.99 | 1.16E-04 | |
| HSD11B2 | Corticosteroid 11-beta-dehydrogenase isozyme 2 | −4.03 | 1.90E-04 | |
| ALDH1A3 | Aldehyde dehydrogenase family 1 member A3 | −2.49 | 1.90E-04 | |
| ALDH3B1 | Aldehyde dehydrogenase family 3 member B1 | −2.38 | 3.44E-05 | |
| HPD | 4-hydroxyphenylpyruvate dioxygenase | −2.55 | 1.70E-05 | |
| Immune response regulation | BDKRB2 | B2 bradykinin receptor | −6.07 | 1.35E-05 |
| CLU | Clusterin | 2.84 | 1.99E-04 | |
| CDH2 | Cadherin-2 | 3.24 | 2.40E-05 | |
| LRRC4C | Leucine-rich repeat-containing protein 4C | 2.30 | 2.23E-04 | |
| HGF | Hepatocyte growth factor | −1.69 | 2.61E-04 | |
| MET | Hepatocyte growth factor receptor | −2.57 | 4.25E-05 | |
| CD276 | CD276 antigen | 2.42 | 3.96E-05 | |
| CNTN1A | Contactin-1a | −1.73 | 3.07E-04 | |
| C3 | Complement C3 | −5.26 | 2.59E-06 | |
| C6 | Complement component C6 | −2.48 | 3.08E-05 | |
| ITGAM | Integrin alpha-M | −2.57 | 3.59E-04 | |
| ITGB2 | Integrin beta-2 | −2.67 | 1.40E-05 | |
| ITGA6 | Integrin alpha-6 | −2.26 | 3.43E-04 | |
| VWF | von Willebrand factor | −2.89 | 9.38E-05 | |
| CD22 | B-cell receptor CD22 | – | 1.40E-04 | |
| A2ML1 | Alpha-2-macroglobulin-like protein 1α2 | −2.89 | 8.88E-06 | |
| IL6ST | Interleukin-6 receptor subunit beta | 3.84 | 2.99E-04 | |
| CXCL12 | Stromal cell-derived factor 1 | −2.86 | 5.68E-05 | |
| TNFRSF14 | Tumor necrosis factor receptor superfamily member 14 | + | 4.34E-06 |
‘-’ indicates the DEG was not expressed in the stressed group; ‘+’ indicates that the DEG was not expressed in the control group.