FIGURE 5.

Selected genes involved in COVID-19-associated stroke were differentially expressed between SARS-CoV-2 positive patients and controls. (A) Four SARS-CoV-2 entry host factors were significantly differentially expressed in nasal tissues from COVID-19 positive patients compared to controls. (B) Stroke-related genes were differentially expressed in peripheral blood mononuclear cell (PBMC) samples from COVID-19 positive patients and controls. The data are represented as a boxplot where the middle line is the median, the lower and upper edges of the box are the first and third quartiles, the whiskers represent the interquartile range (IQR) × 1.5. (C) The bar plot shows the stroke-related genes were upregulated in iPSC–cardiomyocytes after SARS-CoV-2 infection. Adjusted p-value (q) were computed by Benjamini-Hochberg method. The cutoff of differentially expressed genes were | log₂-fold change| > 0.5 and adjusted p-value (q) < 0.05 (Supplementary Tables S5–S8).