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. 2021 Feb 25;11:617289. doi: 10.3389/fonc.2021.617289

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Copyright © 2021 Zhou, Li, Lu, Liu, An, Xiao, Kuo, Wu and He

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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PWP2 enhances the invasion and migration of gastric cancer cells in vitro. (A) The expression of PWP2 in samples from TCGA-STAD Project. (B) Quantitative real-time PCR analysis of PWP2 expression in AGS, SGC7901, MGC803, N87, HGC27, and MKN28 cells. (C) Quantitative real-time PCR analysis of PWP2 expression in PWP2-silenced cells and scrambled-siRNA-treated cells. (D) The migration and invasion abilities of AGS and HGC27 cells were assessed with Transwell assays after the knockdown of PWP2. (Left panel) Representative images of migration (upper) and invasion (lower) assays. (E) The number of cells that migrated or invaded are shown in the histogram. (F) The protein levels of E-cadherin, PWP2, N-cadherin were detected by Western blotting in the PWP2-knockdown group. Data are represented as the mean ± standard deviation of triplicate determinations from three independent experiments. Statistical significance was assessed with an unpaired Student’s t-test (two-tailed test). ***P < 0.001.