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. 2021 Mar 1;12:626515. doi: 10.3389/fphar.2021.626515

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Copyright © 2021 Li, Liu, Li, Qin, Li, Shang, Xing, Gong, Liu and Zhou.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The dose-dependent improvement of enlarged heart area, venous congestion, cardiac output, blood flow velocity, and heart rates in HF zebrafish treated with SYDC for 4 h. (A) The heart areas of the zebrafish in each group. (B) The venous congestion areas of the zebrafish in each group. (C) The cardiac output of the zebrafish in each group. (D) The blood flow velocity of the zebrafish in each group. (E) The heart rates of the zebrafish in each group. ^###Compared with the normal control, p < 0.001; *compared with the model control, p < 0.05; ***compared with the model control, p < 0.001.