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Reduced heart dilatation and venous congestion in HF zebrafish treated with SYDC for 4 h. (A) Vehicle-treated zebrafish; (B) zebrafish treated with verapamil alone; and HF zebrafish treated with digoxin, SYDC-low dose, SYDC-middle dose, and SYDC-high dose, resulting in significantly decreased heart dilatation and venous congestion (C–F). The red-dotted lines indicate the heart area of zebrafish; the yellow-dotted lines indicate the venous congestion area of zebrafish.
