Figure 1.

(A–G) Associations between baseline bone damage in ERA patients with disease burden and systemic bone loss. (A) DAS44 value in ERA patients stratified based on the presence of baseline bone erosions at plain radiographs of the hands and feet, Mann–Whitney U test. (B) IL-6 plasma levels in ERA patients stratified based on the presence of baseline bone erosions at plain radiographs of the hands and feet, Mann–Whitney U test. (C) Rate of systemic bone loss at baseline lumbar spine and femur DEXA in ERA patients (n = 71) stratified based on the presence of baseline bone erosions at plain radiographs of the hands and feet, X² test. (D) Lumbar spine T score value in ERA patients stratified based on the presence of baseline bone erosions at plain radiographs of the hands and feet, Mann–Whitney U test. Correlation between lumbar spine T score value and Sharp (E) and Larsen (F) scores, Spearman rank correlation test. (G) Rate of osteopenia/osteoporosis in ERA patients at baseline stratified based on ACPA positivity, X² test. A p < 0.05 was considered statistically significant. DAS44, Disease Activity Score measured on 44 joints; IL-6, interleukin-6; BMD, bone mineral density; DEXA, dual-energy X-ray absorptiometry.