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Important amino acid metabolism in DCs. IDO1 can affect DC function by tryptophan metabolism. The upregulation of IDO activity leads to the production of Tregs. ARG1 catalyzes arginine to produce ornithine to produce spermine, which can affect IDO1 function through an intermediate pathway. NO, produced by NOS metabolism, inhibits the function of ETC. IDO1, indoleamine 2,3-dioxygenase 1; ARG, arginase; NO, nitric oxide; ETC, electron transport chain.
