Table 2.

Univariate and multivariate Cox proportional hazards models of overall survival.

Risk factor	Univariate analysis			Multivariate analysis
	HR	95% CI	p value		HR	95% CI	p value
Age	1.08	1.02–1.15	0.01		1.09	1.01–1.18	0.02
KPS <70 vs. KPS ≥70	3.74	1.74–8.06	<0.001		9.29	3.27–26.38	<0.0001
Maximal resection
GTR vs. biopsy	0.51	0.28–0.91	0.02		1.72	0.67–4.41	0.26
STR vs. biopsy	0.51	0.23–1.11	0.09		1.01	0.38–2.67	0.98
MGMT methylation
Unmethylated vs. methylated	2.37	1.19–4.72	0.01		2.48	1.09–5.64	0.03
Unknown vs. methylated	2.95	1.37–6.34	0.01		3.58	1.31–9.79	0.01
Hypofractionated vs. standard RT	1.39	0.79–2.44	0.25		1.69	0.68–4.18	0.26
Did not complete vs. completed RT	32.36	9.85–106.3	<0.0001		71.76	13.32–386.6	<0.0001
GTV size	1.01	1.00–1.01	0.06		1.00	0.99–1.01	0.59
Bevacizumab yes vs. no	1.04	0.56–1.64	0.88		0.76	0.38–1.53	0.45

KPS, Karnofsky Performance Status; GTR, gross total resection; STR, subtotal resection; MGMT, O⁶-methylguanine DNA methyltransferase; RT, radiation therapy; GTV, gross target volume.

Data show hazard ratios (HR) and 95% confidence intervals (CI).