Table 1:
Demographic and clinical data and conventional MRI metrics in HC, RRMS, RREM, and PPMS groupsa
| HC 20 (8/12) | RRMS 80 (32/48) | RREM MS 40 (16/24) | PPMS 24 (9/15) |
P Valueb |
|||
|---|---|---|---|---|---|---|---|
| PPMS vs RRMS (RREM) | HC vs RRMS (RREM) | HC vs PPMS | |||||
| Age (yr) | 48.0 (7.3) | 46.9 (7.0) | 48.6 (7.0) | 47.4 (6.8) | .72 (.72) | .72 (.72) | .72 |
| Disease duration (yr) | – | 12.4 (10.7) | 13.2 (11.0) | 7.7 (3.3) | .006c (.006)c | – | – |
| EDSSd | – | 2.5 (2.5) | 4 (0.6) | 4.5 (1.6) | <.001c (.173) | – | – |
| T1LLd | – | 1.1 (1.1) | 1.4 (1.6) | 1.8 (3.3) | .023c (.276) | – | – |
| T2LLd | – | 2.1 (4.9) | 3.6 (7.2) | 2.8 (10.6) | .431 (.923) | – | – |
| BPF (%) | 86.2 (1.5) | 84.2 (2.4) | 83.8 (2.4) | 84.7 (3.0) | .490 (.490) | <.001 (<.001) | .08 |
| CCV (cm3) | 4.6 (0.6) | 4.1 (0.7) | 4.0 (0.7) | 4.1 (0.8) | .690 (.690) | .004 (.001) | .013 |
Note:— – indicates not relevant.
a
The number of participants and the female/male ratio are reported for each group. Unless otherwise indicated, data are reported as mean (SD). Numbers in parentheses in the headers of columns 2–5 are No. of subjects in groups (F/M).
b
Pair-wise comparison (P value). Differences among HC, PPMS, and RRMS (RREM) groups were tested using a t test or Mann-Whitney U test with nonpooled SD (Benjamini-Hochberg correction).
c
Significant.
d
Mann-Whitney U test with nonpooled SD (Benjamini-Hochberg correction) (median and interquartile range).