Fig 6.

T2-weighted images (single-shot fast spin-echo, A–C) and surface reconstructions of 3D steady-state (FIESTA) data of the brain (D–F) in a 21-week gestational age fetus with lobar holoprosencephaly and a severity score of 9/20 (case 20). Axial images of the supratentorial brain (A and B) show interhemispheric fissure formation posteriorly and anteriorly. The third ventricle, temporal horns, and frontal horns of the lateral ventricles are separated. The coronal image (C) shows fusion of the frontal lobes, thalamus, and hypothalamus. The case is complicated by marked frontal lobe hypoplasia and bilateral abnormal frontal sulci shown on the surface reconstructions (D–F).