Fig 5.

Glioblastoma. The left-temporal tumor of a 71-year-old male patient (ID no. 21, On-line Table 1) shows inhomogeneous central and large homogeneous perifocal T2-FLAIR hyperintensities (A). There is a rim-like contrast enhancement of the central tumor portion, as seen on T2-FLAIR (A) and T1-weighted images (B). Na-MR imaging demonstrates a mean NaR:NaT of 1.65 (whole tumor VOI) and 2.02 (CE tumor VOI) (C and D) compatible with GB (Fig 3A, -B; On-line Fig 2G, -H; On-line Table 1). The diagnosis was histopathologically proved (On-line Fig 8). Na-MR images are overlaid onto T1-weighted postcontrast images; color mesh grid: whole tumor VOI, solid color: CE tumor VOI.