Table 1:

Gadolinium-based contrast agents currently approved for clinical use: biochemical properties

Chemical Structure	Trade Name	Thermodynamic Stability Constant	Conditional Stability Constant	Elimination Pathway
Linear
Nonionic
Gadodiamide	Omniscan, 0.5 mmol/mL	16.8	14.9	Renal
Gadoversetamide	OptiMARK, 0.5 mmol/mL	16.6	15	Renal
Ionic
Gadopentetate dimeglumine	Magnevist, 0.5 mmol/mL	22.1	17.7	Renal
Gadobenate dimeglumine	MultiHance, 0.5 mmol/mL	22.6	18.4	93% Renal 3% Biliary
Gadoxetic acid disodium	Primovist, 0.25 mmol/mL	23.5	NA	50% Renal 50% Biliary
Gadofosveset trisodium	Vasovist, 0.25 mmol/mLa	22	NA	91% Renal 9% Biliary
Macrocyclic
Nonionic
Gadoteridol	ProHance, 0.5 mmol/mL	22.8	17.1	Renal
Gadobutrol	Gadavist, 0.5 mmol/mL	21.8	NA	Renal
Ionic
Gadoterate meglumine	Dotarem, 0.5 mmol/mL	25.4	19	Renal

Note:—NA indicates not applicable.

^aBayer Schering Pharma.