Table 2:
SIESTA primary and secondary outcome results according to no or poor (Tan 0–1) and moderate or good collaterals (Tan 2–3)
| Tan 0–1 (n = 48) | Tan 2–3 (n = 56) | P Value | |
|---|---|---|---|
| Primary outcome | |||
| Improvement in NIHSS (mean) (SD) | −1.1 (10.7) | −5.8 (7.6) | .01a |
| Secondary outcomes | |||
| Clinical (No.) (%) | |||
| mRS 0–2 after 3 mo | 10 (20.8) | 14 (25.0) | .82b |
| In-house mortality | 7 (14.6) | 1 (1.8) | .02b |
| Mortality after 3 mo | 12 (25.0) | 15 (26.8) | .84b |
| Logistics (mean) (SD) | |||
| Length of stay in hospital (days) | 6.0 (3.7) | 4.6 (2.6) | .06c |
| Length of stay in ICU (half-days)e | 8.2 (9.2) | 2.7 (2.2) | <.001c |
| Length of ventilation (hr) | 30.1 (5.9) | 3.8 (5.4) | .11c |
| Length of stay on stroke unit (half-days)f | 7.6 (4.3) | 7.0 (4.3) | .5c |
| Onset-to-treatment (IV or IA) (min)g | 122.8 (64.8) | 129.6 (60.9) | .61b |
| Door-to-groin (min) | 71.5 (32.1) | 66.1 (21.4) | .52c |
| Door-to-reperfusion (min)h | 174.8 (57.1) | 165.6 (60.5) | .32c |
| Feasibility of EST (No.) (%) | |||
| Degree of reperfusion (TICI) | .97d | ||
| 0–1 | 3 (6.3) | 5 (9) | |
| 2a | 4 (8.3) | 3 (5.4) | |
| 2b | 24 (50.0) | 25 (44.6) | |
| 3 | 17 (35.4) | 23 (41.1) | |
| Substantial patient movement | 1 (2.1) | 2 (3.6) | .65b |
| Difficult vascular approach | 3 (6.3) | 7 (12.5) | .28b |
| Other | 3 (6.3) | 8 (14.3) | .18b |
| Safety (No.) (%) | |||
| Complications before EST | |||
| Impaired monitor installation | 0 (0.0) | 1 (1.8) | .35b |
| Other | 1 (2.1) | 0 (0.0) | .27b |
| Complications during EST | |||
| Critical ventilation or oxygenation disturbance | 2 (4.2) | 1 (1.8) | .47b |
| Intervention-associated complications | 0 (0.0) | 2 (3.6) | .19b |
| Vessel perforation with ICH and/or SAH complications after EST | 0 (0.0) | 2 (3.6) | .19b |
| Hyper- or hypothermia | 12 (25.0) | 12 (21.4) | .67b |
| Delayed extubation | 17 (35.4) | 12 (21.4) | .11b |
| Ventilation-associated complications | 6 (12.5) | 3 (5.4) | .2b |
| Ventilation-associated pneumonia | 6 (12.5) | 3 (5.4) | .2b |
Note:—IA indicates intra-arterial; min, minimum; max, maximum; ICH, intracerebral hemorrhage; ICU, intensive care unit.
a
ANCOVA, NIHSS as baseline covariate.
b
χ2 test, 2-sided.
c
t test, 2-sided.
d
Mann-Whitney U test, 2-sided.
e
Lower sample size (41 and 46).
f
Lower sample size (31 and 51).
g
Lower sample size (41 and 47).
h
Lower sample size (45 and 49).