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Leigh disease. An 11-year-old girl diagnosed at 2 years of age with Leigh disease. Marked T2 hyperintensity on FLAIR within the dentate nuclei (A and B) and basal ganglia (C). MR spectroscopy with voxel sampling of the basal ganglia (D) demonstrates a prominent lactate doublet (at 1.3 ppm) and elevated choline (at 3.2 ppm).
