Table 4:
Univariate and Multivariate Analysis of Predictors with Neurodevelopmental Performance
| Motor | Language | Cognitive | |||||||
|---|---|---|---|---|---|---|---|---|---|
| Mean Difference | 95% CI | p-value | Mean Difference | 95% CI | p-value | Mean Difference | 95% CI | p-value | |
| Univariate | |||||||||
|
| |||||||||
| BPD Severity | |||||||||
| None | Ref | Ref | Ref | ||||||
| Mild | −2.9 | −12.8 to 7.0 | 0.56 | 3.5 | −7.4 to 14.5 | 0.52 | 7.1 | −3.7 to 17.9 | 0.19 |
| Moderate | −2.8 | −11.8 to 6.3 | 0.54 | 8.5 | −1.5 to 18.5 | 0.094 | 9.2 | −0.7 to 19.0 | 0.068 |
| Severe | −15.6 | −29.9 to −1.2 | 0.034 | −5.9 | −21.8 to 10.0 | 0.46 | −4.7 | −20.4 to 10.9 | 0.55 |
| CSO 1–14 | −4.2 | −8.6 to 0.2 | 0.060 | −0.4 | −5.4 to 4.5 | 0.87 | −0.5 | −5.4 to 4.5 | 0.86 |
| CMAP 1–14a | −0.3 | −1.0 to 0.4 | 0.40 | 0.9 | 0.1 to 1.6 | 0.027 | 0.8 | 0.01 to 1.6 | 0.047 |
| CSO 1–28 | −2.5 | −4.6 to −0.4 | 0.023 | −0.4 | −2.8 to 2.0 | 0.74 | −0.5 | −2.9 to 1.9 | 0.71 |
| CMAP 1–28a | −0.2 | −0.6 to 0.1 | 0.20 | 0.3 | −0.07 to 0.7 | 0.11 | 0.3 | −0.1 to 0.7 | 0.14 |
| WMI | −2.0 | −16.1 to 12.1 | 0.78 | 6.0 | −9.4 to 21.5 | 0.44 | 7.3 | −8.0 to 22.7 | 0.34 |
|
| |||||||||
| Multivariateb | |||||||||
|
| |||||||||
| BPD Severity | |||||||||
| None | Ref | Ref | Ref | ||||||
| Mild | −4.7 | −18.7 to 9.3 | 0.50 | −11.2 | −25.4 to 3.0 | 0.12 | −2.5 | −17.3 to 12.2 | 0.73 |
| Moderate | −7.5 | −22.0 to 7.0 | 0.31 | −12.0 | −26.8 to 2.7 | 0.11 | −6.0 | −21.3 to 9.2 | 0.43 |
| Severe | −15.1 | −37.1 to 7.0 | 0.18 | −23.1 | −45.4 to −0.7 | 0.043 | −15.3 | −38.5 to 7.9 | 0.19 |
| CSO 1–14 | −5.0 | −13.6 to 3.7 | 0.26 | −11.0 | −19.8 to −2.2 | 0.015 | −9.8 | −18.9 to −0.7 | 0.035 |
| CMAP 1–14a | 1.6 | −0.09 to 3.2 | 0.064 | 3.2 | 1.5 to 4.8 | <0.001 | 2.4 | 0.7 to 4.1 | 0.008 |
| WMI | −0.4 | −15.6 to 14.8 | 0.96 | 6.7 | −8.7 to 22.2 | 0.39 | 8.5 | −7.5 to 24.6 | 0.29 |
|
| |||||||||
| Multivariatec | |||||||||
|
| |||||||||
| BPD Severity | |||||||||
| None | Ref | Ref | Ref | ||||||
| Mild | −4.1 | −17.9 to 9.7 | 0.56 | −9.4 | −23.7 to 4.8 | 0.19 | −1.7 | −16.2 to 12.8 | 0.81 |
| Moderate | −7.6 | −22.5 to 7.3 | 0.31 | −10.9 | −26.3 to 4.5 | 0.16 | −5.5 | −21.2 to 10.1 | 0.48 |
| Severe | −13.2 | −36.3 to 9.9 | 0.26 | −20.2 | −44.2 to 3.7 | 0.095 | −12.7 | −37.0 to 11.7 | 0.30 |
| CSO 1–28 | −4.0 | −8.9 to 0.9 | 0.11 | −7.2 | −12.3 to −2.1 | 0.006 | −6.7 | −11.8 to −1.5 | 0.012 |
| CMAP 1–28a | 0.9 | −0.08 to 1.9 | 0.071 | 1.7 | 0.7 to 2.8 | 0.001 | 1.4 | 0.3 to 2.4 | 0.011 |
| WMI | 3.3 | −12.1 to 18.7 | 0.67 | 12.9 | −3.1 to 28.8 | 0.11 | 13.6 | −2.6 to 29.8 | 0.099 |
BPD: bronchopulmonary dysplasia; CSO: cumulative supplemental oxygen; CMAP cumulative mean airway pressure; WMI: white matter injury
a
CMAP 1–14 and CMAP 1–28 divided by 10
b
Multivariate Model: BPD severity, CSO1to14, CMAP1to14, WMI, IVH, and GA
c
Multivariate Model: BPD severity, CSO1to28, CMAP1to28, WMI, IVH, and GA