Fig. 1.

Schematic representation of the overlap between tumor type, TERT promoter, and TP53 mutation. TERT promoter mutation is a powerful marker of poor prognosis irrespective of tumor histotype. TP53 mutation is associated with high mutation burden but the correlation with poor prognosis is not independent of the tumor histotype. PTC: papillary thyroid carcinoma; FTC: follicular thyroid carcinoma; E-FVPTC: encapsulated follicular variant papillary thyroid carcinoma; PDTC: poorly differentiated thyroid carcinoma; WDTC: well-differentiated thyroid carcinoma. BRAF V600E-like and RAS-like: molecular profile according to the Cancer Genome Atlas (TCGA), Integrated Genomic Characterization of Papillary Thyroid Carcinoma [5]. Pink shading indicates those tumor types with a high proportion of TERT promoter mutations. Blue shading indicates those tumor types with a high proportion of TP53 mutations