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. 2021 Feb 4;32(1):63–76. doi: 10.1007/s12022-021-09665-2

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — Sixty-eight-year-old woman with thyroid carcinoma and adrenal metastasis. The thyroid carcinoma has a conventional papillary carcinoma component that is BRAF p.V600E and TERT promoter mutated (C250T) (a), associated to a small focus of anaplastic thyroid carcinoma that in addition to the same BRAF and TERT mutations carries TP53 R249T (b). The adrenal metastasis (c) demonstrates morphology and molecular features (BRAF, TERT promoter, and TP53 mutations) identical to the anaplastic thyroid carcinoma component in the primary tumor