Table 3.

Comparison of survival data, treatment-related mortality, and rate of infections between the age groups in the RICOVER-60 and CHOP-R-ESC trials

	Age	EFS	PFS	OS	TRM	Infections
	Years	3-year rate				CTC
						grade 3,4
RICOVER-60 trial 6xCHOP-14 + 8R (n = 306)
n = 90	61-65	72%	78%	85%	0%	24%
n = 103	66-70	70%	72%	79%	3%	20%
n = 73	71-75	68%	78%	80%	8%	33%
n = 40	76-80	44%	49%	51%	20%	44%
p values (all age groups)		p < 0.001	p < 0.001	p < 0.001	p < 0.001	p = 0.025
p values (76–80 vs. 71–75 years)		p < 0.001	p < 0.001	p < 0.001	p = 0.081	p = 0.263
CHOP-R-ESC trials (n = 561)
n = 149	61-65	74%	78%	85%	1%	10%
n = 188	66-70	68%	75%	80%	4%	18%
n = 141	71-75	71%	74%	77%	4%	24%
n = 83	76-80	55%	57%	61%	11%	28%
p values (all age groups)		p = 0.025	p = 0.007	p = 0.001	p = 0.011	p = 0.001
p values (76–80 vs. 71–75 years)		p = 0.011	p = 0.011	p = 0.045	p = 0.029	p = 0.501