Table 3.
Univariable and multivariable analyses of clinico-pathological factors and serum inflammatory markers; disease-free and overall survival
| Univariable | Multivariable | Univariable | Multivariable | |||||
|---|---|---|---|---|---|---|---|---|
| Disease-free survival | Overall survival | |||||||
| Hazard ratio (95% CI) | p-value | Hazard ratio (95% CI) | p-value | Hazard ratio (95% CI) | p-value | Hazard ratio (95% CI) | p-value | |
|
Age (< 65/65–75 / > 75) |
1.05 (0.78–1.41) | 0.762 | 0.92 (0.71–1.20) | 0.530 | ||||
|
Gender (female/male) |
1.09 (0.58–2.05) | 0.792 | 1.10 (0.63–1.93) | 0.742 | ||||
|
pT stage (1/2/3/4) |
2.01 (1.56–2.58) | < 0.001 | 0.522 | 2.23 (1.74–2.86) | < 0.001 | 0.267 | ||
|
pN stage (0/1/2/3) |
2.07 (1.69–2.54) | < 0.001 | 0.066 | 2.20 (1.84–2.63) | < 0.001 | 1.67 (1.33–2.10) | < 0.001 | |
|
pTNM stage (I/II/III) |
2.63 (1.96–3.54) | < 0.001 | 1.51 (1.00–2.29) | 0.051 | 2.75 (2.09–3.63) | < 0.001 | 0.362 | |
|
Differentiation (well/moderate/poor) |
2.21 (1.44–3.39) | < 0.001 | 0.182 | 2.59 (1.76–3.81) | < 0.001 | 1.58 (1.05–2.36) | 0.027 | |
|
Vascular invasion (no/yes) |
5.26 (3.22–8.60) | < 0.001 | 3.03 (1.75–5.26) | < 0.001 | 4.60 (2.98–7.11) | < 0.001 | 2.87 (1.82–4.52) | < 0.001 |
|
R status (0/1) |
2.49 (1.62–3.82) | < 0.001 | 0.574 | 3.29 (2.34–4.86) | < 0.001 | 0.059 | ||
|
Peri-operative chemotherapy (no/yes) |
2.00 (1.19–3.38) | 0.009 | 0.073 | 1.66 (1.06–2.61) | 0.027 | 0.111 | ||
| C-reactive protein (normal/high) | 1.94 (1.17–3.20) | 0.010 | 0.504 | 1.94 (1.23–3.06) | 0.004 | 0.363 | ||
|
mGPS (0/1/2) |
1.50 (1.10–2.05) | 0.011 | 0.839 | 1.48 (1.11–1.98) | 0.008 | 0.815 | ||
|
NLR (low/high) |
3.08 (1.81–5.24) | < 0.001 | 3.63 (2.11–6.24) | < 0.001 | 2.39 (1.44–3.97) | 0.001 | 2.66 (1.58–4.50) | < 0.001 |