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. 2021 Mar 15;12(3):270. doi: 10.1038/s41419-021-03565-3

Fig. 5. Hsa_circ_0124554 enhances the phosphorylation and prevents the ubiquitination of AKT.

Fig. 5

a The predicted binding region of hsa_circ_0124554 with AKT. b The schematic map of mutant sites. c The phosphorylation of AKT and downstream signaling were detected with IGF1 stimulation. d Ubiquitination of AKT in CRC cells treated with different groups in the presence of IGF1. e The phosphorylation of AKT and downstream signaling were detected with IGF1 stimulation. mut1 indicated mutation in region1, mut2 indicated mutation in region 2. f Ubiquitination of AKT in CRC cells treated with different groups in the presence of IGF1. mut1 indicated mutation in region1, mut2 indicated mutation in region 2.