Table 2.
Monocytes and DCs in cirrhotic patients in relation to the presence of ascites and hepatic encephalopathy.
| Cirrhosis without ascites (n = 42) | Cirrhosis with ascites (n = 26) | p | |
|---|---|---|---|
| Monocytes %, median (range) | 7.38 (1.92–16.57) | 8.51 (3.16–16.70) | 0.065 |
| cMo %, mean ± SD | 6.35 ± 2.61 | 8.19 ± 3.13 | 0.011 |
| cMo†, mean ± SD | 81.84 ± 8.05 | 87.69 ± 7.13 | 0.003 |
| TiMas†, mean ± SD | 18.17 ± 8.05 | 12.43 ± 6.94 | 0.004 |
| DCs %, mean ± SD | 0.25 ± 0.12 | 0.15 ± 0.10 | 0.001 |
| cDC %, mean ± SD | 0.16 ± 0.08 | 0.08 ± 0.06 | < 0.001 |
| cDC‡, mean ± SD | 63.12 ± 13.38 | 55.68 ± 14.55 | 0.033 |
| pDC‡, mean ± SD | 36.88 ± 13.18 | 44.29 ± 14.56 | 0.034 |
| Cirrhosis without HE (n = 49) | Cirrhosis with HE (n = 19) | p | |
|---|---|---|---|
| Monocytes%, median (range) | 7.60 (1.92–16.70) | 8.71 (4.26–15.48) | 0.100 |
| cMo%, mean ± SD | 6.60 ± 2.95 | 8.23 ± 2.65 | 0.039 |
| cMo†, mean ± SD | 82.26 ± 8.20 | 88.76 ± 6.11 | 0.001 |
| iMo†, median (range) | 8.49 (3.20–29.12) | 6.57 (0.29–23.45) | 0.034 |
| NcMo%, median (range) | 0.43 (0.04–1.66) | 0.25 (0.01–0.94) | 0.038 |
| NcMo†, median (range) | 5.72 (0.43–20.97) | 3.70 (0.08–8.68) | 0.009 |
| TiMas†, mean ± SD | 17.74 ± 8.20 | 11.40 ± 5.83 | 0.001 |
| DCs%, mean ± SD | 0.23 ± 0.12 | 0.16 ± 0.12 | 0.042 |
| cDC%, mean ± SD | 0.14 ± 0.08 | 0.09 ± 0.07 | 0.008 |
| cDC mm3, median (range) | 6 (1–18) | 4 (0–13) | 0.014 |
| IL-10, median (range) | 0.24 (0.00–7.46) | 0.92 (0.00–24.25) | 0.001 |
| IL-6, median (range) | 4.06 (0.34–800.95) | 32.48 (4.36–1978.06) | < 0.001 |
cDC Classical dendritic cell, cMo Classical monocytes, DCs Dendritic cells, HE Hepatic encephalopathy, IL Interleukine, iMo Intermediate monocytes, ncMo Nonclassical monocytes, pDC Plasmacytoid dendritic cell, TiMas Tissular macrophages.
†The percentage of monocytes subsets referred to as total monocytes.
‡The percentage of cDC and pDC referred to as total DCs. Statistical differences between groups were calculated using Mann–Whitney U and Student’s T-test tests.