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. 2021 Mar 15;11:6052. doi: 10.1038/s41598-021-85606-7

Figure 1.

Figure 1

Effect of hypercaloric diets on vascular contractility in aorta and pulmonary artery (PA). Typical trace of aorta (a) and pulmonary artery (b) in response to a stimulus of KPSS 80 mM for 3 min, and a dose response curve to different concentrations of PGF2α. (c) Average of the 3 min response to phenylephrine (PE) 1 µM (in PA (n = 15–52) and aorta (n = 9–16) of control, HF and HFHSu animal groups. (d) Dose response to PGF2α (0.03–10 µM) in aorta of control, HF and HFHSu (n = 10 for all) animals. (e) Dose response to PGF2α (0.03–30 µM) in PA of control (n = 21), HF (n = 12) and HFHSu (n = 7) animals. Values are presented as mean ± SD. One-way ANOVA with Dunnet’s Multiple Comparison test. *p < 0.05, **p < 0.01 and ****p < 0.0001 versus control animals; #p < 0.05, ##p < 0.01, ###p < 0.001 and ####p < 0.0001, HF versus HFHSu animals.