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. 2021 Mar 15;11:6052. doi: 10.1038/s41598-021-85606-7

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Effect of type 2 diabetes progression on systemic and local nitric oxide levels and on the expression of eNOS and iNOS. Nitric oxide levels on plasma (a, left panel) and on aorta and pulmonary artery (a, right panel); Average expression of (b) iNOS (130 kDa) and (c) eNOS (140 kDa), and the loading proteins, calnexin (90 kDa) and β-Actin (43 kDa) in the aorta and PA of control (n = 6), HF (n = 5–6) and HFHSu (n = 6) animals. Representative western blots for each protein studied are depicted above the respective graphs. For eNOS expression, the representative bands were cropped due to the sample order in the membrane. For complete membrane image see Supplementary data. Values are presented as scatter plots ± SD; One-way ANOVA with Dunnet’s comparison test. *p < 0.05, **p < 0.01, ***p < 0.001 and ****p < 0.0001 versus control animals; ^##p < 0.01, ^###p < 0.001 and ^####p < 0.0001 comparing the groups submitted to the hypercaloric diets.