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. 2021 Mar 15;11:5892. doi: 10.1038/s41598-021-85353-9

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Female, 51 years old, with lesion located in the outer upper quadrant of the left breast. (a,b) are the subtraction images of CC and MLO views of CESM before NAC, and (c,d) are the subtraction images of CC and MLO views of CESM after two cycles of NAC, respectively. The CC and MLO view grey value reduction percentages were 40.27% and 16.13%, respectively. Before surgery, core needle biopsy confirmed that the patient had invasive breast cancer. After surgical resection, the pathological results showed no invasive cancer components with MP Grade 5.