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. 2021 Mar 15;11:5934. doi: 10.1038/s41598-021-85202-9

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Neutralizing antibody titers and anti-SARS-CoV-2 IgG, IgM responses of COVID-19 patients. (A) The neutralizing antibody titers of serum antibodies against SARS-CoV-2 at an evaluation point of the 75% inhibitory dose (ID75). (B,C) The serum titer against recombinant SARS-CoV-2 spike S1 + S2 protein. (B) Total IgG, (C) IgM, expressed as the OD at 450 nm and the half-maximal binding (OD 50%). (D,E) The serum titer against recombinant SARS-CoV-2 spike RBD protein. (D) Total IgG, (E) IgM, expressed as the OD at 450 nm and the OD 50%. OU, serum samples collected from patients in the ICU of Osaka University Hospital (n = 12); Ju, serum samples collected from patients in Osaka City Juso Hospital (n = 31). All the data are expressed as the mean ± SEM. Statistical evaluation was performed by Mann–Whitney U test (A, common logarithmic transformation); *p < 0.05; **p < 0.01. Graphs made in GraphPad Prism version 8.4.3, https://www.graphpad.com/scientific-software/prism/.

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