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. 2021 Mar 15;11:5934. doi: 10.1038/s41598-021-85202-9

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Linear B cell epitopes on Spike protein of SARS-CoV-2 determined by ELISA. (A) Scheme of predicted linear B cell epitopes in the RBD or other regions of Spike protein in SARS-CoV-2. As shown in red bars, five regions (AH-531, 346–365 aa.; AH-526, 413–432 aa.; AH-527, 442–460 aa.; AH-532, 491–509 aa.; and AH-533, 518–537 aa.) were selected from the RBD, and three regions (AH-528, 146–164 aa.; AH-529, 671–690 aa.; and AH-530, 1146–1164 aa.) were selected from the NTD, S1 and S2 subunits. NTD, N-terminal domain; RBD, receptor-binding domain; RBM, receptor-binding motif; FP, fusion peptide; HR1, heptad repeat 1; HR2, heptad repeat 2; CP, cytoplasm domain. (B,C) The serum titer against synthetic SARS-CoV-2 peptides (AH-526 to AH-533) is expressed as the half-maximal binding (OD 50%). (B) Total IgG and (C) IgM. closed circle, serum samples collected from patients in the ICU of Osaka University Hospital (n = 12); closed square, serum samples collected from patients in Osaka City Juso Hospital (n = 31). All the data are expressed as the mean ± SEM. Statistical evaluation was performed by Mann–Whitney U test; *p < 0.05. Graphs made in GraphPad Prism version 8.4.3. https://www.graphpad.com/scientific-software/prism/.

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