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. 2021 Mar 15;12(3):276. doi: 10.1038/s41419-021-03563-5

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — A RT-qPCR results showed that the expression of PER1 mRNA in TSCCA, SCC15, and CAL27 cells was significantly lower than that in HOMEC cells; B western blot results showed that the expression of PER1 protein in TSCCA, SCC15, and CAL27 cells was significantly lower than that in HOMEC cells; C, D RT-qPCR and western blot results showed that the mRNA and protein expression levels of PER1 in RNAi-PER1-TSCCA cells were significantly decreased, while those in OE-PER1-SCC15 and OE-PER1-CAL27 cells were significantly increased. All data are from three independent experiments. The data are presented as the mean ± SD values (n ≥ 3). *P < 0.05; **P < 0.01; ***P < 0.001; ****P < 0.0001.