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. 2021 Mar 15;11:6062. doi: 10.1038/s41598-021-85581-z

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Sex-difference in the cutoffs of the predicting parameters individually or in combination. (A) The cutoffs of 3 parameters in men and 11 parameters in women having significant (P < 0.05) prediction power (ROC-AUC values > 0.6). A comprehensive comparison between men and women on the cutoffs, ROC-AUC values, sensitivity, specificity, and Youden Index is shown in Table S4. (B) A combination of age, waist, BMI, systolic and diastolic blood pressure, triglyceride, LDL, and HDL in T2D prediction by ROC analysis. (C) A combination of fasting insulin and proinsulin and HbA1c with parameters in (C) for T2D prediction. AUC area under the curve, ***P < 0.001.