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. 2021 Mar 15;7:49. doi: 10.1038/s41420-021-00432-0

Fig. 7. The enhanced autophagy and reduced TDP-43 levels induced by rapamycin treatment decrease E50K-induced apoptosis.

Fig. 7

A, B After treatment with rapamycin, the RGC number in OPTN (E50K) mice significantly increased. Representative images and quantification of viable RGC immunolabelling by NEUN are shown. n = 20. C Light/dark transition test. The time spent in the light box was recorded. Rapamycin reduced the time spent in the light box by E50K mutant mice. n = 8. D Western blot analysis of p62/SQSTM1, LC3 and TDP-43 protein expression in the retinas of mice and E, F quantification of protein expression levels. G The expression of TDP-43 protein was significantly decreased after rapamycin treatment. n = 3. *P < 0.05; **P < 0.01.