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. 2021 Mar 15;11:5897. doi: 10.1038/s41598-021-85242-1

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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In vivo fluorescent images of SAS and HSC-3 tumor-bearing mice after i.v. injections of exosomes. (A) Fluorescent images of whole-body imaging of SAS and HSC-3 tumor-bearing mice after treatment with exosomes. Strong accumulation of fluorescence was observed by whole-mouse imaging in the tumor area. (B) Tumor volume growth curves. (Arrows, i.v. injections of exosomes; data are presented as mean ± SD. N = 5. *P < 0.05). (C) Pictures of local tumors from mice bearing SAS cells or HSC-3 cells. Based upon the series of transplantations, we confirmed that tumor growth was suppressed at considerably higher levels in the octExosome group than in siControl exosome and control groups.