Figure 3.

AURKB inhibition increases apoptosis and induces cell accumulation at the G2/M phase of cell cycle. (a) Total apoptosis in Y79 cells upon treatment with different AURKB inhibitors. (b) The p53 and p21 protein expression levels in inhibitor-treated Y79 cells. (c) Cell cycle distribution of Y79 cells treated with AURKB inhibitors. The cells treated with GSK1070916 were compared with Untreated 1 (*), and the remaining samples were compared with Untreated 2 (#). The error bars represent the standard error of the mean (^*/#P < 0.05, ^**/##P < 0.01 by Student's t-test).