Table 3.
Immunohistochemistry
| Primary ovarian carcinoma | Positive | Negative |
|---|---|---|
| Serous | CK7, CA 125, PAX8, WT1 | CK20 |
| Mucinous | CK7, CK20, MUC5AC (VE), CEA, PAX8 | CA 125 (VE) |
| Endometrioid | CK7, CA 125, HAM54, ER, PR, PAX8 | CK20, CEA |
| Metastatic carcinoma | ||
| Colorectum | CK20, CEA. CDX2 | CK7 (VE in mucinous), CA 125, MUC5AC, HAM56 (VE) |
| Appendix | CK20, MUC5AC (VE), CEA | CK7 (VE), CA 125 |
| Stomach | CK7, CK20 (VE), MUC5AC | CA 125, HAM56 (VE) |
| Breast | GCDFP15, mammaglobin, GATA3, ER (VE), PR (VE) | Vimentin, WT1, CA 125 (VE) |
| Pancreas | CK7, CK20 (VE), MUC5AC, CEA, CA 19-9 | CA 125, HAM56, DPC4 (negative in ~5 0%) |
| Renal | Vimentin, AE1/AE3, CD10, RCC, PAX8 | CK7, CK20 |
| Cervix | p16, CEA, HPV infection | ER, PR |
VE variable expression