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Temporal course of changes in FRDA. Diagram illustrating the contrasting temporal course of clinical changes in FRDA along with serum NfL levels over time (amalgamated from Bridel et al., 2019; Del Prete et al., 2020; Wang et al., 2020). Clinical changes are presented based on the clinical course of an early onset individual (onset between ages 5−10). At present, no study has measured NfL in the presymptomatic period before age five.
