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. 2021 Mar 2;11:610547. doi: 10.3389/fonc.2021.610547

Figure 4.

Figure 4

NEAT1_2 regulates TGM2 via downregulating miR-491. (A) Identification of 22 common miRNAs that bind to both NEAT1_2 and TGM2 from four publicly available datasets (A: RegRNA 2.0, B: miRDB, C: Targetcan, and D: ENCORI). Different colored areas represent different datasets. (B) The 22 miRNAs that bind to both NEAT1_2 and TGM2 from bioinformatic prediction. (C) The relative expression levels of miR-19b, miR-135b, and miR-491 were detected using qRT-PCR in PTC cells transfected with si-NEAT1_2 or NC. Data are presented as the mean ± S.D., as analyzed using an independent samples t-test. **P < 0.01 versus NC. (D) Protein expression of TGM2 was detected using western blotting in PTC cells transfected with miR-19b mimic, miR-135b mimic, and miR-491 mimic or NC. Data are presented as the mean ± S.D., as analyzed using an independent samples t-test. **P < 0.01 versus NC.