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The effect of heat shock protein 90 (Hsp90) on drug-induced apoptosis. Flow cytometry analysis and apoptotic rates in A2780 and A2780/Taxol cells transfected with shNC or shHsp90 for 24 h, or incubated with 1 μM BIIB021 for 24 h, followed by treatment with 0.4 μM paclitaxel (A–L) or 2 μM cisplatin for 48 h (M–X), as indicated. Data are expressed as mean ± SD of 3 for each experimental group. *P < 0.05.
