Table 3.
Significant associations between multiparametric maps and CSF NfL, N = 50 (t-test). Results are corrected at a voxel-wise threshold of p < .001, using a cluster-wise threshold of p < .05FWE.
| Cluster number | Hemisphere | Cluster Size | T value (cluster peak) | pFWE − corr | Cluster peak coordinates MNI (mm) (x, y, z) | Degrees of freedom | ||
|---|---|---|---|---|---|---|---|---|
| R2* Map | Grey matter | Cluster 1 | Right | 455560 | 4.79 | p < .001 | 33, -68, 44 | 1, 45 |
| Cluster 2 | Left | 1561 | 4.46 | p < .001 | -10, 45, -19 | |||
| Cluster 3 | Left | 9705 | 4.30 | p < .001 | -52, -72, 35 | |||
| Cluster 4 | Right | 1000 | 3.91 | p < .001 | 56, -58, 17 | |||
| White matter | Cluster 5 | Right | 603 | 3.86 | p < .001 | 18, -66, 38 | 1, 45 | |
| Cluster 6 | Left | 273 | 3.66 | p = .003 | -20, -71, 25 |