Table 4.
Univariate and Multivariate Analyses of Factors Associated with Overall Survival by Cox Proportional Hazards Models
| Variable | Univariate | Multivariate | |||||
|---|---|---|---|---|---|---|---|
| HR | 95% CI | p-value | HR | 95% CI | p-value | ||
| Age, yr | |||||||
| ≤70 | 1.000 | ||||||
| >70 | 1.316 | 0.780–2.220 | 0.303 | ||||
| Sex | |||||||
| Male | 1.000 | ||||||
| Female | 1.461 | 0.947–2.256 | 0.087 | ||||
| Body mass index, kg/m2 | |||||||
| ≤23 | 1.000 | ||||||
| >23 | 0.802 | 0.517–1.243 | 0.324 | ||||
| ECOG performance status | |||||||
| 0 | 1.000 | ||||||
| 1 and 2 | 0.917 | 0.590–1.425 | 0.700 | ||||
| Tumor location | |||||||
| Head | 1.000 | ||||||
| Body and tail | 0.819 | 0.530–1.265 | 0.367 | ||||
| Tumor size, cm | |||||||
| ≤3 | 1.000 | ||||||
| >3 | 1.644 | 1.051–2.569 | 0.029 | ||||
| Node involvement | |||||||
| No | 1.000 | ||||||
| Yes | 0.711 | 0.395–1.281 | 0.256 | ||||
| Resectability classification | |||||||
| Borderline resectable | 1.000 | ||||||
| Locally advanced | 2.332 | 1.390–3.910 | 0.001 | ||||
| Serum CA 19-9 at diagnosis, U/mL | |||||||
| ≤37 | 1.000 | ||||||
| >37 | 1.580 | 0.853–2.926 | 0.146 | ||||
| Biliary drainage | |||||||
| No | 1.000 | ||||||
| Yes | 1.066 | 0.637–1.783 | 0.809 | ||||
| FOLFIRINOX dose reduction | |||||||
| No | 1.000 | ||||||
| Yes | 1.184 | 0.757–1.853 | 0.458 | ||||
| Serum CA 19-9 lowest, U/mL | |||||||
| ≤37 | 1.000 | ||||||
| >37 | 2.445 | 1.545–3.868 | <0.001 | 2.178 | 1.376–3.446 | 0.001 | |
| Resection after FOLFIRINOX | |||||||
| No | 1.000 | ||||||
| Yes | 0.213 | 0.109–0.416 | <0.001 | 0.233 | 0.119–0.455 | <0.001 | |
HR, hazard ratio; CI, confidence interval; ECOG, Eastern Cooperative Oncology Group; CA 19-9, carbohydrate antigen 19-9.