Table 5.
Univariate and Multivariate Analyses of Factors Associated with Overall Survival in the Subgroup with Initial FDG-PET Images by Cox Proportional Hazards Models
| Variable | Univariate | Multivariate | |||||
|---|---|---|---|---|---|---|---|
| HR | 95% CI | p-value | HR | 95% CI | p-value | ||
| Age, yr | |||||||
| ≤70 | 1.000 | ||||||
| >70 | 1.244 | 0.504–3.067 | 0.635 | ||||
| Sex | |||||||
| Male | 1.000 | ||||||
| Female | 1.099 | 0.547–2.206 | 0.791 | ||||
| Body mass index, kg/m2 | |||||||
| ≤23 | 1.000 | ||||||
| >23 | 0.611 | 0.292–1.279 | 0.191 | ||||
| ECOG performance status | |||||||
| 0 | 1.000 | ||||||
| 1 and 2 | 0.663 | 0.322–1.366 | 0.266 | ||||
| Tumor location | |||||||
| Head | 1.000 | ||||||
| Body and tail | 0.647 | 0.316–1.326 | 0.234 | ||||
| Tumor size, cm | |||||||
| ≤3 | 1.000 | ||||||
| >3 | 1.386 | 0.688–2.793 | 0.361 | ||||
| Node involvement | |||||||
| No | 1.000 | ||||||
| Yes | 0.882 | 0.303–2.563 | 0.817 | ||||
| Resectability classification | |||||||
| Borderline resectable | 1.000 | ||||||
| Locally advanced | 2.816 | 1.321–6.005 | 0.007 | ||||
| Serum CA 19-9 at diagnosis, U/mL | |||||||
| ≤37 | 1.000 | ||||||
| >37 | 1.513 | 0.577–3.971 | 0.400 | ||||
| Biliary drainage | |||||||
| No | 1.000 | ||||||
| Yes | 1.214 | 0.538–2.740 | 0.640 | ||||
| FOLFIRINOX dose reduction | |||||||
| No | 1.000 | ||||||
| Yes | 1.415 | 0.609–3.291 | 0.419 | ||||
| Serum CA 19-9 lowest, U/mL | |||||||
| ≤37 | 1.000 | ||||||
| >37 | 3.114 | 1.385–7.001 | 0.006 | 3.674 | 1.549–8.715 | 0.003 | |
| Resection after FOLFIRINOX | |||||||
| No | 1.000 | ||||||
| Yes | 0.202 | 0.076–0.539 | 0.001 | 0.290 | 0.102–0.825 | 0.020 | |
| FDG-PET SUVmax | |||||||
| ≤8.4 | 1.000 | ||||||
| >8.4 | 3.096 | 1.516–6.322 | 0.002 | 2.540 | 1.149–5.613 | 0.021 | |
HR, hazard ratio; CI, confidence interval; ECOG, Eastern Cooperative Oncology Group; CA 19-9, carbohydrate antigen 19-9; FDG-PET, 18F-fluorodeoxyglucose positron emission tomography; SUVmax, maximum standardized uptake value.