Table 3.

Cox proportional hazards modelling of common variant genetic risk scores in association with specific causes of death in Swedish cases of schizophrenia (Genomics subset, n = 1253 SCZ cases who died).

			Common variant genetic risk scores
Cause of death	Died from specific cause, n	Died from other cause, n	SCZ	Cognitive ability	BMI	Coronary artery disease	Total cholesterol	Chronic kidney disease	Smoking	Type 2 diabetes
Any cancer	227	1026	1.08 (0.93–1.27)	0.79 (0.68–0.92, P = 0.002)	0.94 (0.81–1.08)	0.99 (0.87–1.14)	1.01 (0.88–1.15)	1.13 (0.98–1.29)	0.86 (0.75–0.98)	0.94 (0.81–1.09)
Breast cancer	11	1242	1.59 (0.74–3.44)	0.65 (0.31–1.40)	0.78 (0.38–1.60)	1.24 (0.62–2.50)	0.54 (0.27–1.07)	1.01 (0.51–1.99)	0.72 (0.37–1.43)	0.70 (0.32–1.50)
Lung cancer	66	1187	0.97 (0.72–1.31)	0.87 (0.66–1.16)	1.08 (0.83–1.40)	0.96 (0.75–1.23)	1.05 (0.82–1.34)	0.99 (0.77–1.28)	0.71 (0.55–0.91)	0.91 (0.69–1.19)
Cardiovascular disease	323	930	0.99 (0.87–1.12)	0.94 (0.83–1.06)	0.94 (0.84–1.06)	0.95 (0.84–1.06)	0.98 (0.88–1.09)	0.99 (0.88–1.11)	0.97 (0.87–1.09)	1.08 (0.95–1.22)
Stroke	60	1193	0.88 (0.65–1.20)	1.04 (0.78–1.39)	0.95 (0.72–1.25)	0.94 (0.72–1.24)	0.91 (0.70–1.18)	0.94 (0.72–1.23)	1.20 (0.92–1.55)	0.97 (0.73–1.28)
External causes	75	1178	1.17 (0.89–1.54)	1.00 (0.77–1.29)	1.12 (0.88–1.44)	0.96 (0.76–1.22)	1.08 (0.86–1.35)	1.06 (0.84–1.35)	0.98 (0.78–1.24)	0.97 (0.75–1.25)
Suicide	31	1222	0.86 (0.56–1.31)	0.85 (0.57–1.27)	0.90 (0.62–1.32)	0.90 (0.61–1.32)	0.66 (0.46–0.94)	0.89 (0.62–1.29)	0.87 (0.60–1.25)	0.72 (0.49–1.06)
Other causes	391	862	1.01 (0.89–1.14)	1.07 (0.95–1.20)	1.01 (0.91–1.13)	1.02 (0.92–1.13)	1.05 (0.95–1.16)	0.94 (0.84–1.04)	1.01 (0.91–1.12)	0.97 (0.87–1.08)

Hazard ratios (95% confidence interval) are presented. No effects statistically significant at the Bonferroni-adjusted p value. All exposures (genetic risk scores) are included in a single model along with the first five ancestry principal components.