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. 2021 Mar 15;11:5878. doi: 10.1038/s41598-021-85412-1

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Tacrine, but not duloxetine, promotes restoration of locomotor activity. (a) Representative tracking image of a 5-min recording at 8 dpf. Quantification of (b) total distance moved (control: 1476.41 ± 975.90, MTZ: 539.10 ± 369.30, recovery: 655.05 ± 441.90, 250 nM tacrine: 1093.44 ± 670.50, 10 μM duloxetine: 243.87 ± 383.45), (c) velocity (control: 1.64 ± 1.09, MTZ: 0.60 ± 0.41, recovery: 0.73 ± 0.49, 250 nM tacrine: 1.19 ± 0.75, 10 μM duloxetine: 0.27 ± 0.42), (d) total movement time (control: 327.08 ± 200.34, MTZ: 120.81 ± 90.72, recovery: 148.80 ± 109.57, 250 nM tacrine: 252.45 ± 176.18, 10 μM duloxetine: 50.55 ± 113.43), and (e) total resting time (control: 572.91 ± 200.34, MTZ: 779.18 ± 90.72, recovery: 751.19 ± 109.57, 250 nM tacrine: 647.54 ± 176.18, 10 μM duloxetine: 549.44 ± 113.43) during 15-min recordings. The experiment was independently repeated three times (n = 31 per group). Error bars indicate mean ± standard deviation. ***p < 0.001; **p < 0.01; *p < 0.05; n.s., not significant.