Table 3.
Multivariate analysis of prognostic markers in the whole group.
| Whole cohort | HR (95% CI) | P valueb | |
|---|---|---|---|
| Model 1 | |||
| Minimal TFD (I) | 0.85 (0.77; 0.94) | 0.002 | |
| Number of positive LN | 1.14 (1.05; 1.23) | 0.001 | |
| Model 2 | |||
| TFD (I) binariseda | ≤3.5 (ref. >3.5) | 4.58 (1.52; 13.80) | 0.007 |
| LN positivity | Yes (ref. no) | 3.79 (1.83; 7.81) | <0.001 |
| Model 3 | |||
| TFD (I) binariseda | ≤3.5 (ref. >3.5) | 4.57 (1.50; 13.97) | 0.008 |
| LN positivity | Yes (ref. no) | 3.76 (1.67; 8.50) | 0.001 |
| LVSI | Yes (ref. no) | 1.01 (0.45; 2.28) | 0.976 |
| Model 4 | |||
| TFD (I) binariseda | ≤3.5 (ref. >3.5) | 3.48 (0.71; 17.00) | 0.123 |
| LN positivity | Yes (ref. no) | 5.02 (2.26; 11.14) | <0.001 |
| Stromal invasion (P) | 1.00 (0.94; 1.07) | 0.989 | |
| Model 5 | |||
| TFD (I) binariseda | ≤3.5 (ref. >3.5) | 4.13 (1.16; 14.69) | 0.029 |
| LN positivity | Yes (ref. no) | 3.8 (1.82; 7.92) | <0.001 |
| Tumour type | Adeno (ref. squamo) | 1.39 (0.26; 7.49) | 0.700 |
| Adenosquamo (ref. squamo) | 1.24 (0.2; 7.78) | 0.816 | |
| Model 6 | |||
| Largest tumour size (P) binariseda | >32.5 (ref. ≤32.5) | 2.29 (1.16; 4.49) | 0.016 |
| LN positivity | Yes (ref. no) | 3.78 (1.94; 7.36) | <0.001 |
adeno adenocarcinoma, CI confidence interval, LN lymph node, LVSI lymphovascular space invasion, squamo squamous cell cancer, TFD tumour-free distance, (I) assessed by imaging, (P) assessed by pathology.
aCut-off determined by ROC analysis, the criterion was the highest value of the sum of sensitivity and specificity. blevel of significance P < 0.05.