Table 4.
Multivariate analysis of prognostic markers in LN-negative patients.
| LN-negative patients | HR (95% CI) | P valueb | |
|---|---|---|---|
| Model 1 | |||
| Minimal TFD (I) | 0.9 (0.81; 1.01) | 0.079 | |
| Tumour type | Adeno (ref. squamo) | 1.46 (0.46; 4.59) | 0.521 |
| Adenosquamo (ref. squamo) | 6.87 (1.82; 25.92) | 0.004 | |
| Model 2 | |||
| TFD(I) binariseda | ≤3.5 (ref. >3.5) | 3.57 (1.15; 11.09) | 0.028 |
| Tumour type | Adeno (ref. squamo) | 1.48 (0.47; 4.66) | 0.506 |
| Adenosquamo (ref. spino) | 6.41 (1.70; 24.22) | 0.006 | |
| Model 3 | |||
| TFD (I) binariseda | ≤3.5 (ref. >3.5) | 3.93 (1.25; 12.39) | 0.020 |
| Tumour type | Adeno (ref. squamo) | 1.47 (0.47; 4.63) | 0.511 |
| Adenosquamo (ref. squamo) | 5.83 (1.53; 22.24) | 0.010 | |
| LVSI | Yes (ref. no) | 0.60 (0.19; 1.88) | 0.383 |
| Model 4 | |||
| TFD (I) binariseda | ≤3.5 (ref. >3.5) | 2.90 (0.51; 16.34) | 0.229 |
| Tumour type | Adeno (ref. squamo) | 1.46 (0.38; 5.58) | 0.580 |
| Adenosquamous (ref. squamo) | 2.18 (0.27; 17.95) | 0.468 | |
| Stromal invasion (P) | 1 (0.89; 1.13) | 0.959 | |
| Model 5 | |||
| Largest tumour size (P) binariseda | >25.5 (ref. ≤25.5) | 1.35 (0.58; 3.13) | 0.480 |
| Tumour type | Adeno (ref. squamo) | 2.37 (0.94; 5.95) | 0.067 |
| Adenosquamous (ref. squamo) | 7.53 (2.05; 27.68) | 0.002 |
adeno adenocarcinoma, CI confidence interval, LN lymph node, LVSI lymphovascular space invasion, squamo squamous cell cancer, TFD tumour-free distance, (I) assessed by imaging, (P) assessed by pathology.
aCut-off determined by ROC analysis, the criterion was the highest value of the sum of sensitivity and specificity; blevel of significance P < 0.05.