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. 2021 Mar 15;11:5877. doi: 10.1038/s41598-021-85230-5

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Analysis of RNAseq data with respect to response to oxygen tension. (A) PCA plot displaying either control-iPSC-derived trophoblast (left), or PE-iPSC-derived trophoblast (right). Trophoblast derived from control-iPSC separate much more clearly based on oxygen tension, compared to those derived from PE-iPSC. (B) Venn diagram displaying the number of DEGs between different oxygen tensions (2% vs. 21%) within the same disease condition (control and PE). Boxed numbers indicate DEGs unique to either iPSC group, with gene symbols indicating a handful of these unique genes in trophoblast derived from control-iPSC. (C) PCA plot displaying only long non-coding RNAs (lncRNAs) in either control-iPSC-derived trophoblast (left), or PE-iPSC-derived trophoblast (right). Based on analysis of this RNA subset, trophoblast derived from control-iPSC again separate much more clearly based on oxygen tension, compared to those derived from PE-iPSC. (D) Venn diagram displaying the number of differentially expressed lncRNAs between different oxygen tensions (2% vs. 21%) within the same disease condition (control and PE). Boxed numbers indicate number of differentially expressed lncRNAs unique to either iPSC group, with gene symbols indicating unique lncRNAs in either group.