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. 2021 Mar 15;11:5877. doi: 10.1038/s41598-021-85230-5

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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DNA methylation analysis, comparing iPSCs to their cells-of-origin. (A) PCA plot displaying methylation data from our 6 mesenchymal stem cells (MSC) and 18 MSC-derived iPSC (3 iPSC clones per MSC), and previously-obtained methylation data from human dermal fibroblasts (HDF) and HDF-derived iPSCs. (B) Table displaying the number of differentially expressed probes (DMP) shared with H9/WA09 human embryonic stem cell line, using Venn diagrams. Overlapping probes of each combination were compared, with each cell type having a higher number of overlapping DMPs when compared to iPSC of the same cell-of-origin. DMPs were determined using a Δβ-value of 0.3 or above; cross reacting and sex chromosome probes were excluded from this analysis.