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. 2021 Mar 15;11:5877. doi: 10.1038/s41598-021-85230-5

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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DNA methylation analysis with respect to iPSC phenotype. (A) Table displaying the number of DMPs between PE and control MSC, undifferentiated iPSC, and iPSC at day + 4 of differentiation (at either 2% or 21% oxygen) (n = 6 for each comparison). DMPs were determined using a Δβ-value of 0.3 or above; cross reacting and sex chromosome probes were excluded from this analysis. (B) Average β-value plot showing PE and control at day + 4 differentiation, with genomic regions around coding genes. (C) Venn diagram showing the number of DMPs (based on trichotomized data), hyper- or hypo- methylated in either control- or PE-iPSC-derived trophoblast, with summary of GREAT output and top 10 GO terms from DMPs uniquely hypomethylated in control-iPSC derived trophoblast under 2% oxygen, displayed in the right panel.