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. 2021 Mar 15;12:1669. doi: 10.1038/s41467-021-21928-4

Fig. 1. High-dimensional single-cell analysis of CD8+ T cells identifies higher proportion of activated effector memory T cells in responders.

Fig. 1

A Heatmap showing the iMFI of specific markers in discrete Phenograph clusters. Ballons indicate the median frequency of each cluster amongst responders and non-responders. Statistical analysis by two-sided Mann–Whitney nonparametric test, Bonferroni’s multiple comparisons test, *p = 0.046. B Proportion of cell within each cluster for each individual. Data represent individual values, mean (center bar) ± SEM (upper and lower bars). Statistical analysis by two-sided Mann–Whitney nonparametric test, Bonferroni’s multiple comparisons test; T0, ***p < 0.0001; T1, *p = 0.046; T2 p = 0.037. T0 = before therapy, T1 = after 1 cycle of therapy, T2 = after two cycles of therapy. Individual measurements of NR = 9, R = 8. Source data are provided as a Source Data file.