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. 2021 Mar 15;11:171. doi: 10.1038/s41398-021-01290-1

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — Cell type fractions were determined across all brain regions for OCD subjects (purple) and unaffected comparison subjects (grey) separately. Gene expression patterns in single-cell data were used to estimate the fraction of eight broadly defined cell types: astrocytes, ependymal cells, excitatory neurons, immune cells, interneurons, oligodendrocytes, medium spiny neurons (a.k.a. spiny projection neurons), and vascular cells. A Cell type fractions for global analysis (combined OFC, caudate, and nucleus accumbens). B Cell type fractions in the OFC, C Caudate, and D Nucleus accumbens. Boxplots are displayed, where ** indicates p < 0.01 and * indicates p < 0.05 (uncorrected for multiple comparisons). The mean cell type fractions were computed based on all four brain regions; however, when the cell type did not exist in the brain region, it was not included in the calculation. Thus, the mean cell type fraction for the excitatory neurons was based only on the cortical regions and the mean cell type fraction for spiny projection neurons was based on the caudate and nucleus accumbens regions.