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. 2021 Mar 15;11:161. doi: 10.1038/s41398-020-01177-7

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© The Author(s) 2021, corrected publication 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — A Relative changes (in per cent, %) in anandamide (AEA) plasma levels before and after fear extinction (day 2) grouped in quartiles (quartile 1: high increase (n = 13), quartile 2: low increase (n = 13), quartile 3: low decrease (n = 12), quartile 4: high decrease (n = 13)). Error bars denote standard errors of the mean. B Average subjective anxiety ratings before (pre) and after (post) fear extinction (day 2) for the CS⁺ grouped according to changes in AEA (quartiles 1–4). A rating of 0 indicates no feeling of fear in association with the stimulus, 10 indicates the greatest fear. Error bars denote standard errors of the mean. C Group-wise (AEA quartile model) comparison of cerebral networks showing an exponential decay during fear extinction learning. Significance was assessed at p < 0.001 (voxel level) and p < 0.05 (FWE-corrected) at the cluster-level (corresponding to 169 voxels). The statistical parametric map was overlaid on sagittal sections of the group averaged T1 image. For demonstration purposes, fMRI sectional views were extracted from more conservative analyses with smaller cluster sizes. Coordinates refer to MNI space. MFG middle frontal gyrus, IPL inferior parietal lobule, INC increase in AEA during fear extinction, DEC decrease in AEA during fear extinction.