Table 1.
WHO/FIGO staging and classification of gestational trophoblastic diseasea.
| GTN: FIGO staging and classification (Washington, 2000) | ||||
|---|---|---|---|---|
| FIGO anatomic staging: | ||||
| Stage I: Disease confined to the uterus | ||||
| Stage II: GTN extends outside of the uterus, but is limited to the genital structures (adnexa, vagina, broad ligament) | ||||
| Stage III: GTN extends to the lungs, with or without known genital tract involvement | ||||
| Stage IV: All other metastatic sites |
| Modified WHO prognostic scoring system as adapted by FIGO | ||||
|---|---|---|---|---|
| Prognostic factors | Score | |||
| 0 | 1 | 2 | 4 | |
| Age (years) | <40 | ≥40 | – | – |
| Antecedent gestation | Mole | Abortion | Term | – |
| Intervalb (months) | <4 | 4–6 | 7–12 | >12 |
| Pretreatment serum hCG (IU/l) | <103 | 103 to <104 | 104 to <105 | >105 |
| Largest tumour size (including uterus) | <3 | 3 to 4 | ≥5 | – |
| Site of metastases | Lung | Spleen, kidney | Gastrointestinal tract | Brain, liver |
| Number of metastases | – | 1–4 | 5–8 | >8 |
| Previous failed chemotherapy | – | – | Single drug | Two or more drugs |
WHO/FIGO World Health Organization/International Federation of Gynecology and Obstetrics, GTN Gestational trophoblastic neoplasia, hCG Human chorionic gonadotropin.
aThis Table has been reproduced from FIGO Oncology Committee (2002), FIGO staging for gestational trophoblastic neoplasia 2000. Int. J. Gynaecol. Obstet. 77, 285–287 with permission. © John Wiley and Sons (Copyright License Number 4945060393283).
bInterval (in months) between the end of antecedent gestation (when known) and the beginning of chemotherapy.